2027 Summer Intern - Computational Science

Roche • Santa Clara, CA • 2h ago

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

The Position

We advance science so that we all have more time with the people we love .

Department Summary

The XOOS Algorithm Development team leads secondary analysis algorithm development for Sequencing by Expansion (SBX) data on the AXELIOS platform. We bridge rapid R&D prototyping with production-grade bioinformatics tools, driving multi-omics whole genome and targeted sequencing applications across oncology, genetic disease, and infectious disease.

This internship position is fully remote.

The Opportunity

Algorithm Development.

Benchmarking.

Software development.

Presenting results to stakeholders.

Program Highlights

Intensive 12-weeks, full-time (40 hours per week) paid internship.

Program start dates are in May/June (Summer).

A stipend, based on location, will be provided to help alleviate costs associated with the internship.

Ownership of challenging and impactful business-critical projects.

Work with some of the most talented people in the biotechnology industry.

Who You Are

Required Education:

Must be pursuing a PhD (enrolled student).

Required Majors: Bioinformatics, Computer Science, Computational Biology.

Required Skills

Advanced experience developing bioinformatics algorithms for secondary analysis of sequencing data.

Demonstrated expertise in detecting genetic variation in challenging genomic @contexts, including repeat regions, paralogs, pseudogenes, and highly homologous loci.

Strong understanding of haplo@type phasing, read alignment, local or de novo assembly, scaffolding, and pangenome methods.

Experience developing tools for one or more of the following:Repeat expansion or repeat-geno@type analysis, Paralog- or pseudogene-aware variant calling, Long-read or highly accurate sequencing analysis, Haplo@type reconstruction and phasing, De novo or targeted assembly, Graph genomes or pangenome analysis.

Strong programming skills in Python and/or C++, with experience building reproducible, tested software.

Experience evaluating algorithms with representative datasets and quantitative performance metrics.

Currently enrolled in or recently graduated from a degree program in bioinformatics, computational biology, computer science, statistics, mathematics, genomics, or a related field.

Preferred Knowledge, Skills, and Qualifications

Demonstrated record of publications, preprints, or equivalent technical contributions describing novel algorithms or methods for variant detection and genotyping.

Research experience focused on difficult-to-map regions of the genome, including repeats, paralogs, pseudogenes, segmental duplications, and other highly homologous loci.

Publications or documented contributions involving one or more of the following:Repeat-variant detection or genotyping, Haplo@type phasing and reconstructionLocal, targeted, or de novo assembly, Scaffolding and contig generation, Pangenome or graph-based analysisLong-read sequencing analysis, Paralog- or pseudogene-aware variant calling.

Ability to explain algorithmic innovations, validation methodology, limitations, and performance results clearly.

Evidence of translating research methods into reproducible proto@types or usable bioinformatics tools.

Relocation benefits are not available for this job posting.

The expected salary range for this position based on the primary location of California is $47.00-$52.00 per hour. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for paid holiday time off benefits.

Who we are

A healthier future drives us to innovate. Together, more than 100'000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let's build a healthier future, together.

Roche is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants (https://docs.google.com/forms/d/e/1FAIpQLSdZWlsbfQOvFVIQgHE_iDzWUTlhZvj6FytIzjS7xq6IGh1H5g/viewform) .

Roche

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