Back to Jobs search

Purification Scientist

System One • Boston, MA • 5h ago

Job Title: Purification Scientist - Downstream Process Development

Location: Boston, MA

Hours/Schedule: Monday-Friday, 8 am to 5 pm

Compensation: $40.00 - $45.40/hr

Type: 12 month contract, Potential for extension or conversion to permanent

Overview

The Purification Scientist supports downstream process development for viral vectors, biologics, and recombinant proteins. This role focuses on executing and optimizing purification workflows, generating high-quality data, and supporting manufacturing readiness under GMP/GLP-aligned practices. The ideal candidate brings strong hands-on chromatography and ultracentrifugation experience, with the ability to troubleshoot processes and collaborate across technical teams.

Responsibilities

Execute purification workflows including CsCl density gradient ultracentrifugation, affinity chromatography (e.g., AVB, CaptureSelect), ion-exchange chromatography (AEX, CEX), and polishing steps

Operate AKTA systems (Avant, Pure, or Pilot) to perform small- to large-scale purification runs

Perform tangential flow filtration (TFF) for concentration and buffer exchange of intermediates and final products

Design and execute experiments to support process optimization and development initiatives

Collect, analyze, and document data in accordance with established procedures and GMP/GLP best practices

Perform analytical characterization using methods such as UV spectroscopy, SDS-PAGE, ddPCR, ELISA, and HPLC

Troubleshoot purification challenges and recommend process improvements

Collaborate cross-functionally with upstream development, analytical, and manufacturing teams

Maintain laboratory equipment, prepare buffers, manage chromatography columns, and ensure compliance with safety and documentation standards

Qualifications

Required:

Master's degree in Biology, Biochemistry, Chemical Engineering, Biotechnology, or related field

Minimum 2 years of hands-on purification experience in academic or industry settings

Practical experience with CsCl density gradient ultracentrifugation, ion-exchange chromatography, and affinity purification

Experience with buffer preparation and purification process fundamentals

Understanding of analytical methods for biologic or viral vector characterization

Strong documentation practices and attention to detail

Preferred:

Experience with AAV or other viral vector purification using CsCl density gradients and column chromatography

Experience operating AKTA systems and Unicorn software

Familiarity with regulated laboratory environments supporting GMP or GLP activities

Benefits

System One offers eligible employees health and welfare benefits coverage options, including medical, dental, vision, spending accounts, life insurance, voluntary plans, and participation in a 401(k) plan.

Ref: #558-Scientific

System One, and its subsidiaries including Joulé, ALTA IT Services, CM Access, TPGS, and MOUNTAIN, LTD., are leaders in delivering workforce solutions and integrated services across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible full-time employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan.

System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.

Similar Jobs

Department Director - Pediatrics Tufts Medical Center

Tufts Medicine • Boston, MA • 4h ago

Hospital & Medical

Tufts Medical Center is a world-renowned academic medical center that has been providing exceptional care across New England for over two centuries. Our clinicians are dedicated to delivering innovative, patient-centered...

4h ago

Go to Apply

USA - Medical Reviewer - III - USD

System One • Cambridge, MA • 4h ago

Hospital & Medical

Job Title: USA - Medical Reviewer - III - USD Location: Fully Remote - Must be based in US Type: Contract - 1 year Compensation: $80.00 - $115/hr Overview Exciting opportunity to work direct with a leading global pharmac...

4h ago

Go to Apply

Cleanroom Technician

Aerotek • Danvers, MA • 4h ago

IT & Engineering

Job Title: Assembler Entry level - no previous experience required - on the job paid training available Shift : Monday - Friday 7:00am - 3:00pm Shift : Monday - Friday 3:30pm - 11:30pm Pay : $22/hour + 50 cent raises aft...

4h ago

Go to Apply

Lead AI Engineer

Capital One • Cambridge, MA • 5h ago

IT & Engineering

Lead AI Engineer Overview At Capital One, we are creating responsible and reliable AI systems, changing banking for good. For years, Capital One has been an industry leader in using machine learning to create real-time,...

5h ago

Go to Apply

GCP Quality Governance Operations Lead (Sr. Manager)

Parexel • Boston, MA • 5h ago

Management & Administrative

Parexel FSP is looking for a GCP Quality Governance Operations Lead in Argentina. The GCP Quality Governance Operations Lead is responsible for providing strategic and operational expertise to drive the management (plann...

5h ago

Go to Apply

Scientist III, Research and Development (Chromatography Resin R&D)

ThermoFisher Scientific • Bedford, MA • 5h ago

Work Schedule Standard (Mon-Fri) Environmental Conditions Adherence to all Good Manufacturing Practices (GMP) Safety Standards, Laboratory Setting, Some degree of PPE (Personal Protective Equipment) required (safety glas...

5h ago

Go to Apply

Structural Lead Engineer

AECOM • Chelmsford, MA • 5h ago

IT & Engineering

Company Description Work with Us. Change the World. At AECOM, we're delivering a better world. Whether improving your commute, keeping the lights on, providing access to clean water, or transforming skylines, our work he...

5h ago

Go to Apply

AWS Sales Engineer - Data & AI

Accenture • Boston, MA • 8h ago

Sales & Marketing

We Are: Accenture is a leading global professional services company that helps the world's leading businesses, governments and other organizations build their digital core, optimize their operations, accelerate revenue g...

8h ago

Go to Apply

Azure Pre Sales Engineer - Data & AI

Accenture • Boston, MA • 8h ago

Sales & Marketing

8h ago

Go to Apply

Business Analyst

Actalent • Woburn, MA • 8h ago

IT & Engineering

Job Title: Business AnalystJob Description This role provides hands-on technical and functional support for Teamcenter X, focusing on CAD data management and SolidWorks integration. The engineer will collaborate closely...

8h ago

Go to Apply

Subscribe to get new jobs sent directly to you
(no charge, cancel anytime)

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.