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ADME Biotransformation Scientist
Company:** Eli Lilly and Company
Job Summary
Eli Lilly and Company is seeking a highly motivated and skilled ADME Biotransformation Scientist to join our dynamic team. In this role, you will play a critical part in understanding the metabolic fate of novel therapeutic candidates, contributing directly to drug discovery and development programs.
Job Responsibilities
Design, implement, and interpret in vitro and in vivo biotransformation studies to elucidate metabolic pathways, identify metabolites, and determine mechanisms of drug metabolism.
Apply and develop innovative analytical techniques, including LC-MS/MS and high-resolution mass spectrometry, for metabolite identification, quantification, and structural elucidation.
Conduct experiments to assess drug-drug interaction potential, including reaction phenotyping and enzyme induction/inhibition studies.
Collaborate cross-functionally with medicinal chemists, pharmacologists, toxicologists, and other ADME scientists to integrate biotransformation data into drug discovery and development strategies.
Prepare detailed scientific reports, presentations, and contribute to regulatory submissions.
Evaluate and implement new technologies and methodologies to enhance biotransformation capabilities.
Mentor junior scientists and contribute to a culture of scientific excellence and continuous learning.
Maintain accurate and thorough laboratory records and ensure compliance with all safety and regulatory guidelines.
Job Qualifications
Bachelor's degree with 6+ years of relevant industry experience
Experience with LC-MS/MS and high-resolution mass spectrometry for metabolite identification and structural characterization.
Experience in vitro ADME assays, including microsomal stability, hepatocyte metabolism, and reaction phenotyping.
Experience with drug metabolism enzymes (e.g., CYPs, UGTs, FMOs) and their role in drug disposition.
Experience designing experiments, troubleshooting technical issues, and interpret complex data independently.
Additional Skills/Preferences:
Master's degree with 3+ years of relevant industry experience
Early career Ph.D. in Pharmaceutical Sciences, Pharmacology, Analytical Chemistry, Biochemistry, or a related scientific discipline with 0-3 years of post-doctoral or industry experience in ADME/DMPK, specifically focusing on biotransformation. Solid expertise in LC-MS/MS and high-resolution MS for metabolite identification
Demonstrated hands-on experience in in vitro drug metabolism and biotransformation studies
Excellent written and oral communication skills, with a proven ability to present scientific findings clearly and concisely. Strong collaborative spirit and ability to work effectively in a multidisciplinary team environment. Familiarity with regulatory guidelines related to drug metabolism and pharmacokinetics is a plus.
Proven ability to work independently in a fast-paced research environment
High standards for data quality, reproducibility, and scientific integrity.
Interest in assay development, automation, or innovative analytical strategies
Understanding pharmacokinetics, ADME and proficiency to communicate theory and concepts clearly
Interest in data analysis and digital tools that enhance experimental biotransformation research
Ability to balance multiple projects and handle competing responsibilities
Collaborative team behaviors and aspiration to build and sustain relationships with R&D customers and the wider scientific community
Exposure to modalities beyond small molecules would be considered a plus
Experience in drug discovery and development
Experience authoring regulatory and technical reports
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$66,000 - $222,200
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
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