Senior Scientist, Mass Spectrometry

Insmed Inc. • Bridgewater, NJ • 7h ago

At Insmed, every moment and every patient counts - and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you'll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person's contributions to meaningful progress. That commitment has earned us recognition as Science magazine's No. 1 Top Employer for five consecutive years, certification as a Great Place to Work in the U.S., and a place on The Sunday Times Best Places to Work list in the UK.For patients, for each other, and for the future of science, we're in. Are you?About the Role:We're looking for a highly motivated and experienced bioanalytical scientist to help us expand what's possible for patients with serious diseases. Reporting to the Associate Principal Scientist, the Senior Scientist, Mass Spec will employ their broad knowledge of mass spectrometry for applications ranging from discovery to early-stage development. This individual will also participate in unbiased proteomic biomarker discovery experiments (e.g., LFQ, TMT) in various biological matrices and independently develop targeted assays for protein biomarker quantitation (e.g., LC-MS/MS, MSD, ELISA) to empower drug development. Additionally, the Senior Scientist will assist in characterizing protein therapeutics by mass spectrometry (e.g., peptide mapping, intact, native) for early phase pipeline advancement. Additional future opportunities to expand existing capabilities include metabolomics, lipidomics, CE-MS, CDMS, and other bioanalytical technologies (e.g., SPR, Jess, BLI) are anticipated.What You'll Do: In this role, you'll have the opportunity to Independently develop LC-MS/MS (i.e., Sciex 7500+) assays for protein target quantitation by robust sample preparation (i.e., protein extraction, proteolysis, etc.), assignment of appropriate signature peptide, establishment of analytical figures-of-merit (i.e., linearity, sensitivity, etc.), and method qualification in representative biological matrices. You'll also: Perform unbiased proteomic experiments for biomarker discovery by employing proteomic workflows, including appropriate experimental design, reproducible sample preparation, high resolution mass spectrometry data acquisition (Thermo Astral, Eclipse, Excedion), bioinformatic data analysis (i.e., ProteomeDiscoverer, MaxQuant, PEAKS, etc.), and results interpretation. Expand upon current sample preparation workflows to include affinity-enrichment and offline fractionation approaches for identification and characterization of low-abundance protein analytes. Identify and/or employ complementary bioanalytical techniques (e.g., ELISA, MSD, Western-blot) for better understanding of biological results while working closely with internal SMEs for executing experiments of most value. Contribute to the routine analysis of therapeutic protein candidates, including peptide mapping, intact/native protein analysis, data acquisition and reporting to provide analytical support of various research projects. Assist the group in lab maintenance and housecleaning, ensuring optimum instrument operation and readiness (i.e., calibration, QA/QC), stocking of reagents/supplies/chemicals, proper waste disposal, sample inventory and CTU management, and strict adherence to safety protocols.Who You Are:You have at least a Bachelor's degree in Chemistry, Analytical Chemistry, Biochemistry or a related scientific discipline and a strong focus on proteomic analysis using HRMS and QQQ mass spectrometry platforms. Additionally, you have: 5+ years of hands-on experience in applying advanced mass spectrometry techniques for both unbiased protein biomarker discovery and targeted protein quantitation by LC-MS/MS. Experience with broad sample preparation methodologies, automation, and instrumentation (Thermo, Sciex). Ability to create and perform SRM/MRM experiments on QQQ in

Similar Jobs

Executive Director, U.S. HCP Marketing, KarXT ADP

Bristol Myers Squibb • Princeton, NJ • 6h ago

Sales & Marketing

Working with Us Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every...

6h ago

Go to Apply

Marketing Ops & Effectiveness Transformation - Senior Director

PwC • Florham Park, NJ • 6h ago

Sales & Marketing

Specialty/Competency: IFS - Clients & Markets Industry/Sector: Not Applicable Time Type: Full time Travel Requirements: Up to 20% At PwC, our people in brand management, marketing and sales focus on collaboration to...

6h ago

Go to Apply

Senior Manager, Congress Operations & Planning

Bristol Myers Squibb • Princeton, NJ • 7h ago

Management & Administrative

7h ago

Go to Apply

Human Capital Payroll Strategy and Operate Manager-Human Capital/IIO

Deloitte • Princeton, NJ • 7h ago

Finance, Accounting & Banking

Payroll Strategy and Operate Manager - IIO Job Description 2-6-26 Deloitte's Human Capital Offering Portfolio Our Human Capital practice is at the forefront of transforming the nature of work. As converging forces reshap...

7h ago

Go to Apply

Human Capital Payroll Strategy and Operate Manager-Human Capital/IIO

Deloitte • Morristown, NJ • 7h ago

Finance, Accounting & Banking

7h ago

Go to Apply

Consumer and Business Banking, Senior Relationship Banker, South Amboy, NJ

Santander US • South Amboy, NJ • 9h ago

Finance, Accounting & Banking

It Starts Here: Santander is a global leader and innovator in the financial services industry and is evolving from a high-impact brand into a technology-driven organization. Our people are at the heart of this journey an...

9h ago

Go to Apply

Software Engineer

MetLife • Bridgewater, NJ • 15h ago

IT & Engineering

Location: Hybrid schedule. Must be commutable to the following office location: Bridgewater, NJ Key Responsibilities Design, develop, test, and deploy software applications (Full Stack Development) using modern programmi...

15h ago

Go to Apply

Sr. Full Stack Software Engineer

Deloitte • Princeton, NJ • 15h ago

IT & Engineering

Sr. Full-Stack Software Engineer - CL5 Role Overview: As a Lead Engineer (Data Lifecycle Management) , you will take a hands-on role in designing, building, and operating data platform capabilities that govern how data i...

15h ago

Go to Apply

Sub-Assembly / Wire Harness Assembler

Magna Power Electronics, Inc. • Flemington, NJ • 15h ago

Manufacturing & Warehouse

Magna-Power Electronics, a Flemington, New Jersey based electronics manufacturer, is seeking a Sub-Assembly / Wire Harness Assembler to join its dedicated world class team. With continued growth and recipient of the 2020...

15h ago

Go to Apply

IT Intern (Application Development & Website Design)

Horizon Blue Cross Blue Shield of New Jersey • Newark, NJ • 20h ago

IT & Engineering

Horizon Blue Cross Blue Shield of New Jersey empowers our members to achieve their best health. For over 90 years, we have been New Jersey's health solutions leader driving innovations that improve health care quality, a...

20h ago

Go to Apply

Subscribe to get new jobs sent directly to you
(no charge, cancel anytime)

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.