POSITION SUMMARY
As a Scientist on our Antibody-Drug Conjugate (ADC) Biology team, you will play a pivotal role in driving the development of next-generation ADCs for cancer therapy. Through collaborative, cross-functional research spanning early discovery to clinical development, you will help shape innovative therapeutic strategies that address unmet medical needs.
In this role, you will design and implement robust biological assays and screening strategies to evaluate novel payload chemo@types and uncover their mechanisms of action. You will help identify cancer indications most susceptible to these payloads and optimize their pairing with tumor-associated antigens to enhance therapeutic efficacy. You will analyze, interpret, and clearly communicate experimental data to multidisciplinary teams and key stakeholders. You may contribute to the generation of IND- and BLA-enabling data packages, supporting regulatory submissions and clinical advancement. You may integrate clinical insights-such as signatures of sensitivity and resistance-into early-stage discovery efforts to inform future therapeutic concepts.
This position offers the opportunity to work at the forefront of ADC innovation, contributing to a dynamic pipeline and helping translate cutting-edge science into transformative cancer treatments.
KEY RESPONSIBILITIES
Apply cellular, proteomic, and molecular biology laboratory techniques to preclinical research projects in the area of cancer biology
Execute molecular and cell-based methodologies including flow cytometry, immunohistochemistry, cytotoxicity assays, reporter assays, ELISA, alpha-LISA, western blotting, WES and in vitro PD assays
Investigate novel antibody drug conjugate (ADC) targets, linker payloads, and new MOAs of our therapeutics through development, optimization, and execution of complex assays
Independently design, execute, analyze and document key experiments to enable clear go/no-go decisions; present findings to large and small audiences
Provide leadership within technical area of expertise; may train others
Maintain rigorous records of experimental progress using electronic laboratory notebooks
MINIMUM REQUIREMENTS
Bachelor's Degree in Biology, Biochemistry, Engineering, Immunology or a related field and 6+ years of relevant industry ADC Biology or small molecule experience OR
Master's degree in Biology, Biochemistry, Engineering, Immunology or a related field and 4+ years of relevant industry ADC Biology or small molecule experience
Experience with tissue culture and diverse molecular biology techniques
Experience with protein quantification methods, e,g, WES, western blotting
Proficiency in flow cytometry analysis
Experience working in and adapting to a rapidly evolving environment
Experience working independently and as part of a team
Experience leveraging critical thinking to address challenges and overcome obstacles
Strong written and verbal communication skills including experience communicating effectively to a wide range of audiences
Excellent organization and planning skills
PREFERRED REQUIREMENTS
Knowledge of therapeutic antibodies, protein degraders, and/or ADCs
Knowledge of epigenetics, signal transduction, and/or metastasis pathways
Experience with cell-based assay development for screening purposes
Experience with immunohistochemistry, immunofluorescence, and/or imaging
Experience with utilization and analysis of data from 'omics platforms
Proficiency with appropriate software for data analysis
PHYSICAL/MENTAL REQUIREMENTS
Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Occasional need to work non-standard hours. Occasional travel needs (1-2 times per year). Must adhere to safe work practices and procedures.
Work Location Assignment: On Premise
The annual base salary for this position ranges from $77,100.00 to $128,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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Research and Development
