2026 Summer Intern - Integrative Immunogenomics

Genentech • South San Francisco, CA • 1h ago

The Position

Department Summary

The Human Genetics organization advances discovery and translational science by integrating large-scale genomic data with disease biology to generate insights that inform drug discovery and precision medicine. Our work spans autoimmune disease, inflammation, and oncology, with a strong emphasis on immune-mediated mechanisms and causal inference.

This internship provides doctoral-level trainees with the opportunity to contribute to high-impact, business-critical research at the intersection of human genetics, immunology, and computational biology.

This internship position is located in South San Francisco, on-site.

The Opportunity

As an Integrative Immunogenomics Intern, you will lead a focused research project leveraging whole-genome sequencing data and advanced variant calling outputs to understand how structural variation, somatic variation, and HLA diversity influence immune pathways relevant to disease risk and therapeutic response.

Analyze whole-genome sequencing datasets to characterize structural variants, clonal hematopoiesis (CHIP) events, and HLA class I/II variation in immune-related genes.

Integrate genomic findings with immune pathway and gene-set resources (e.g., Reactome, InnateDB, Open Targets).

Assess associations between genetic features and immune or inflammatory pheno@types across selected disease areas, including autoimmunity and immune-oncology.

Summarize results at the gene- and pathway-level to support ongoing pathobiology mapping and translational research efforts.

Communicate findings through a final written report and oral presentation to cross-functional scientific stakeholders.

Program Highlights

Intensive 12-week, full-time (40 hours per week) paid internship.

Program start dates are in May/June (Summer)

A stipend, based on location, will be provided to help alleviate costs associated with the internship.

Ownership of challenging and impactful business-critical projects.

Work with some of the most talented people in the biotechnology industry.

Who You Are (Required)

Required Education: You meet the following criteria:

Must be pursuing a PhD (enrolled student).

Required Majors: Must be pursuing a PhD in Genetics, Genomics, Bioinformatics, Immunology, Computational Biology, or a closely related field.

Required Skills:

Demonstrated experience analyzing genomic or high-dimensional biological data.

Strong programming skills in Python, R, or similar analytical languages.

Solid foundation in human genetics and molecular biology concepts.

Ability to synthesize complex data into clear, actionable insights.

Excellent written and verbal communication skills.

Preferred Knowledge, Skills, and Qualifications

Experience with whole-genome sequencing data and variant interpretation.

Familiarity with structural variants, somatic variation, or HLA typing.

Background or strong interest in immune biology, autoimmunity, or cancer immunology.

Experience working in collaborative, multidisciplinary research environments.

Complements our culture and the standards that guide our daily behavior & decisions: Integrity, Courage, and Passion.

Relocation benefits are not available for this job posting.

The expected salary range for this position based on the primary location of California is $50.00 per hour. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for paid holiday time off benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants (https://docs.google.com/forms/d/e/1FAIpQLSdZWlsbfQOvFVIQgHE_iDzWUTlhZvj6FytIzjS7xq6IGh1H5g/viewform) .

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