2026 Summer Intern - Immunogenicity & Bioanalytical Sciences

Genentech • South San Francisco, CA • 7h ago

The Position

Department Summary

Our BioAnalytical Sciences Department is a world-class bioanalytical center of excellence for novel strategies, technologies, and methods that enable the development of life-changing medicines. We do this by fostering an innovative and collaborative environment that values and recognizes diversity of contributions.

We are seeking a highly motivated intern to join our team for the summer of 2026. The successful candidate for this multidisciplinary laboratory-based position will work closely with our scientific team to evaluate the physiological relevance of primary dendritic cell (DC) models used for immunogenicity risk assessment and specifically their implementation in immunopeptidomics or MAPPs (MHC-associated peptide proteomics) assays.

The intern will use advanced cell biology techniques, flow cytometry and high-resolution mass spectrometry to investigate how culture microenvironments influence antigen processing and presentation kinetics. This is a unique opportunity to apply deep immunological expertise to translational drug development questions.

The internship position is full time and located in South San Francisco, on-site **.

The Opportunity**

Cell Model Characterization: Lead the culture, maintenance, and phenotypic characterization of primary human monocyte-derived dendritic cells (mo-DCs).

Assay Execution: Perform immunopeptidomics/ MAPPs workflows to isolate and identify MHC-associated peptides from biological samples.

Flow Cytometry: Design and execute multicolor flow cytometry panels to assess cell viability, maturation markers, and pheno@type stability.

Data Integration: Work with immunopeptidomics & proteomics differential expression datasets.

Communication: Present research findings in periodic written reports and oral presentations to the wider department.

Program Highlights

Intensive 12-weeks, full-time (40 hours per week) paid internship.

Program start dates are in May/June 2026.

A stipend, based on location, will be provided to help alleviate costs associated with the internship.

Ownership of challenging and impactful business-critical projects.

Work with some of the most talented people in the biotechnology industry.

Opportunity to learn and implement immunopeptidomics methods on cutting-edge high-resolution LC/MS instruments (i.e. Orbitrap Astral).

Gain a broader understanding of the role of in vitro models in the non-clinical immunogenicity risk assessment pipeline.

Professional & personal development curriculum throughout the program, including networking opportunities, workshops, and panel discussions.

Who You Are

Required Education

Must be pursuing a PhD (enrolled student).

Required Majors: Immunology, Analytical Chemistry, Biochemistry or a related Biological discipline.

Required Skills:

Extensive hands-on experience with primary immune cell culture , specifically the isolation, generation and maintenance of monocyte-derived dendritic cells (mo-DCs) .

Demonstrated ability to be highly motivated and work independently.

Preferred Knowledge, Skills & Qualifications

Excellent communication, collaboration, and interpersonal skills.

Complements our culture and the standards that guide our daily behavior & decisions: Integrity, Courage, and Passion.

Proficiency in multicolor flow cytometry, including panel design, acquisition, and analysis (e.g., FlowJo).

Theoretical understanding of proteomics/ immunopeptidomics sample preparation and immunoaffinity capture.

Familiarity with differential expression analysis (i.e., volcano plots, pathway analysis).

Familiarity with running analysis scripts using computational data science tools (i.e. 'R', Python).

Relocation benefits are not available for this job posting.

The expected salary range for this position based on the primary location of California is $46.00 hour. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for paid holiday time off benefits.

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants (https://docs.google.com/forms/d/e/1FAIpQLSdZWlsbfQOvFVIQgHE_iDzWUTlhZvj6FytIzjS7xq6IGh1H5g/viewform) .

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