Advanced Process Modeling Expert

Takeda Pharmaceuticals • Cambridge, MA • 17h ago

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Job Description

About the role

As an Advanced Process Modeling Expert , you will develop, deploy, and maintain advanced process models and digital twins that drive control and optimization strategies across manufacturing processes, both for unit-operations and end-to-end. Developing custom code, leveraging digital modeling tools, and robust data infrastructure, you will develop mechanistic, hybrid, or AI/ML-based models for dynamic simulation, forecasting and soft-sensing. Your work will enhance process understanding, support tech transfers, and strengthen overall process capability and product quality.

How you will contribute

Develop mechanistic, hybrid, and statistical/ML models for unit operations (e.g., bioreactors, chromatography, filtration, UF/DF), applying first principles like mass & energy balances, reaction kinetics, thermodynamics, and transport phenomena.

Build dynamic digital twins for scenario analysis, scale-up/scale-down evaluation, material-balance verification, and manufacturing tech transfer readiness.

Own the full lifecycle of digital process models, from conceptual design to implementation, deployment, monitoring, and retraining.

Prepare and structure data for dry-lab simulations by integrating sensor/historian, batch records, and Manufacturing Sciences lab data.

Develop soft sensors for non-measurable or slow-to-measure process parameters using mechanistic ?correlations, ML regression, and hybrid approaches.

Drive manufacturing optimization initiatives such as cycle-time reduction, yield improvement, process robustness studies, root-cause analyses, and failure-mode simulations.

What you bring to Takeda

Bachelor's degree in a STEM field (Chemical or Biochemical Engineering preferred); Master's or PhD is an advantage.

Minimum of 3 years in pharmaceutical manufacturing, familiar with cGMP requirements.

Experience in digitizing industrial processes, computational modeling, process simulation, soft-sensor development, and data analytics.

Proficiency in AI, machine learning, and statistical methods for data-driven decision-making.

Strong expertise in scientific modeling: mechanistic and hybrid modeling; experience with flow-sheeting software such as gPROMS.

Familiarity with Discoverant, SIMCA Online/Offline, OSI PI, Databricks, and AWS is a plus.

Strong programming skills in Python (Julia is a plus).

Familiarity with Agile project management (Scrum/Kanban in Jira) is advantageous.

Clear communicator capable of explaining technical concepts to non-experts.

Curious and open to leveraging new digital tools and methodologies to improve industrial processes.

Fluent in English

More about us:

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Empowering our people to shine:

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, or any other characteristic protected by law.

Locations

Zurich, SwitzerlandCambridge, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

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