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RayzeBio, a Bristol Myers Squibb company, is a dynamic biotechnology company headquartered in San Diego, CA. The company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio is developing innovative drugs against targets of solid tumors. Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals .
The Executive Director, Early Development will provide leadership and strategic direction in developing RayzeBio's portfolios from development candidate through early POC and Phase I/II studies. This role will work closely with research and translational medicine, engage across several solid tumor assets, and contribute to clinical development plans. The Executive Director may directly supervise the work of Early Clinical Development physicians, clinical scientists and medical physicists. The role will be foundational in working with teams in R&D to provide Clinical expertise from discovery through POC transitions, providing insights into biology, translational elements, as well as overall benefit-risk assessments. The role will report directly to the CMO, RayzeBio, and will be a member of the Clinical Development leadership team.
Job Responsibilities:
Essential duties and responsibilities include the following. Other duties may be assigned.
Strategy & Execution
Oversees and/or designs and develops clinical studies and research plans in support of asset strategy with the research and clinical team; clinical studies include early human imaging studies, first-in-human Phase I, proof of concept Phase I/II, entry registrational studies, biomarker qualification studies, and/or clinical pharmacology studies "
Strategic and technical management of multiple/complex active early development programs in partnership with research and translational medicine" "
Contributes to and participates in formal protocol review and provides approval as appropriate "
Contributes to overall strategy for specific disease/indications while ensuring an overall portfolio view "
Liaises with clinical leadership and upper management to define clinical strategy, including dose and schedule, indications, and patient selection (e.g., biomarker qualification and implementation)
Presents and/or articulates clinical strategy to senior leadership across the enterprise to support progression of portfolio" "
Leads search and evaluation activities on business development due diligence efforts, and provides advice to strategic transactions group""
Participates in medical monitoring activities"as needed for early-phase clinical trials and works with CROs engaged in the conduct of such trials
Medical Monitoring
Oversees and/or serves as Medical Monitor for clinical trials from Phase 1 through Proof-of-Concept by Articulating and executing clinical development strategy"
In collaboration with cross-functional teams, analyzes, interprets, and acts on emerging Clinical Trial data.
Serves as principal functional author for Regulatory submissions, study reports, and publications "
Leadership and Matrix Management ""
May be responsible for managing Clinical Development Physicians, scientists, and medical physicists"
Champions a quality-focused mindset and ensures adherence to GCP and compliance obligations for clinical conduct "
Establishes an effective and ethical culture that encourages teamwork, peer review, promotes cooperation, and provides a supportive culture"
Develops a culture that values diversity of thought, supports coaching, fosters accountability and integrity, and promotes process excellence and continuous improvement "
Ensures appropriate stakeholder Engagement and Communication
May be required to represent RayzeBio in business development due diligence and partner alliance management as appropriate; sits on JDC/JRC/JSC as appropriate "
Travel:
Domestic and International travel may be required (30%)"
Education and Experience:
Advanced degree(s) in relevant field: MD or MD/PhD and deep clinical expertise in subject matter "
Subspecialty fellowship training in Oncology is required"
Knowledge of radiation physics, radiobiology and clinical oncology strongly preferred"
Track record of contributions to field (e.g., publications, patents, keynote participation in conferences, etc.); leadership/faculty roles within relevant professional/scientific/medical societies""
Skills and Qualifications:
10+ years of relevant experience in discovery, translational, and/or clinical research in an academic or industry setting, where applicable
Leadership experience required (e.g., managed a team, led a cross-functional team)"
Deep understanding of biology, targets, and translational science"related to radiopharmaceuticals
Comfortable with cross-functional drug and product development teams and management in a matrix environment""
Must be skilled at interacting externally and at speaking engagements""
Must be skilled at attracting, developing, and retaining skilled professionals"
T he starting compensation for this job is a range from $267,000 - 334,000 plus incentive cash and stock opportunities (based on eligibility). The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience.
RayzeBio
If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as Transforming patients' lives through science , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
On-site Protocol
BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy @type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ (https://careers.bms.com/eeo-accessibility) eeo-accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/
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Company: Bristol-Myers Squibb
Req Number: R1591162
Updated: 2025-04-21 05:49:55.055 UTC
Location: Remote
Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.
