2026 Summer Intern - Radiochemistry/Organic Chemistry (Department of Translational Imaging)

Genentech • South San Francisco, CA • 4h ago

The Position

Department Summary

The Translational Imaging department accelerates drug discovery and development by developing non-invasive imaging strategies to visualize biodistribution and target engagement in vivo. Our team integrates chemistry, biology, and physics to design novel imaging agents and methodologies across multiple modalities, including MRI, Optical, CT, PET, and SPECT. We are dedicated to creating advanced chemical tools and imaging solutions that provide critical insights into disease biology and therapeutic efficacy.

This internship position is located in South San Francisco, on-site.

The Opportunity

Synthesize and characterize novel small molecule precursors and standards (specifically bioorthogonal handles) for CNS imaging applications.

Perform bioconjugation workflows to attach chemical handles to antibody fragments (VHH) and conduct rigorous purification.

Evaluate the stability and reaction kinetics of imaging probes in complex biological environments.

Gain experience with radiochemistry optimization and the development of pretargeting systems (e.g., TCO-Tetrazine).

Apply critical thinking to troubleshoot synthetic routes and assay designs.

Contribute to Genentech's culture of scientific curiosity and discovery via cross-department presentations.

Program Highlights

Intensive 12-weeks, full-time (40 hours per week) paid internship.

Program start dates are May/June, 2026.

A stipend, based on location, will be provided to help alleviate costs associated with the internship.

Ownership of a challenging and impactful project.

Work with some of the most talented people in the biotechnology industry.

Who You Are

Required Education:

Must be pursuing a PhD (enrolled student).

Required Majors: Chemistry, Radiochemistry, Chemical Biology, Organic Chemistry, or a related field.

Required Skills:

Strong foundation in organic synthesis and characterization of small molecules.

Familiarity with modern analytical techniques (HPLC, LCMS, NMR etc.).

Basic understanding of or experience with protein bioconjugation techniques.

Ability to work safely and efficiently in a chemistry laboratory setting.

Preferred Knowledge, Skills, and Qualifications

Knowledge of bioorthogonal chemistry (click chemistry) and its applications.

Interest or experience in radiochemistry (F-18 labeling) or imaging sciences.

Excellent communication, collaboration, and interpersonal skills.

Complements our culture and the standards that guide our daily behavior & decisions: Integrity, Courage, and Passion.

Relocation benefits are not available for this job posting.

The expected salary range for this position based on the primary location of California is $46.00 hour. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for paid holiday time off benefits.

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants (https://docs.google.com/forms/d/e/1FAIpQLSdZWlsbfQOvFVIQgHE_iDzWUTlhZvj6FytIzjS7xq6IGh1H5g/viewform) .

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