Job Description
Our large pharmaceutical client is seeking an Associate Scientist to join their growing Biophysics & Molecular Attributes Group in Spring House, PA. The Biophysics & Molecular Attributes Group within Biologics Discovery uses innovative biophysical, biochemical, and mass spectrometry based analytical tools to help select best therapeutic candidates for clinical development. You will be a critical member of the Higher Order Structure (HOS) team that characterizes developability attributes like thermal stability, chemical stability, solubility, and aggregation on a broad range of biologics platforms including monoclonal antibodies, multi-specific antibodies, antibody drug conjugates, antibody radio conjugates, and other therapeutic proteins. You will design and perform experiments using a variety of technologies like HPLC, DSF, DSC, cIEF, GXII, DLS, and more.
Key Responsibilities:
Execute automated methods for biophysical and structural characterization of antibody therapeutics. Integrate robotic liquid handling systems (e.g., Hamilton, Tecan) with analytical platforms to improve efficiency, consistency, and sample throughput.
Execute analytical analysis of biologics candidates using a wide variety of technologies such as size-exclusion HPLC, plate-based HIC/Heparin binding, DSF.
Evaluate results to deliver scientifically supported conclusions and recommendations that are documented in appropriate technical reports.
Maintain lab and equipment.
Collaborate with colleagues in the global organization to support discovery projects.
Assist in developing recommendations for improving standard procedures.
We are a company committed to creating diverse and inclusive environments where people can bring their full, authentic selves to work every day. We are an equal opportunity/affirmative action employer that believes everyone matters. Qualified candidates will receive consideration for employment regardless of their race, color, ethnicity, religion, sex (including pregnancy), sexual orientation, gender identity and expression, marital status, national origin, ancestry, genetic factors, age, disability, protected veteran status, military or uniformed service member status, or any other status or characteristic protected by applicable laws, regulations, and ordinances. If you need assistance and/or a reasonable accommodation due to a disability during the application or recruiting process, please send a request to HR@insightglobal.com.To learn more about how we collect, keep, and process your private information, please review Insight Global's Workforce Privacy Policy: https://insightglobal.com/workforce-privacy-policy/.
Skills and Requirements
Master's or Bachelor's Degree in a related field of study
Minimum of 2 year of experience characterizing proteins
Experience using HPLC, DSF, DSC, cIEF, GXII, or DLS
Mass Spectrometry experience is highly preferred
