Scientist - Target Discovery

Lilly • Boston, MA • 5h ago

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

The Target Discovery team is seeking a motivated and committed Scientist, with deep experience in molecular biology, to contribute to the development of gene therapy-based solutions for sensory disorders. A successful candidate will work independently and perform benchwork that supports early discovery efforts, including but not limited to design and execution of screens for candidate therapeutic targets across the Lilly Gene Therapy preclinical portfolio and in vitro and ex vivo assays to test potential leads. The successful candidate will be self-motivated and a creative and expansive thinker, with a desire to succeed in a highly collaborative and fast-paced environment.

Job Responsibilities:

Execute in vitro and ex vivo nonclinical experiments for the development of genetic medicines, including the following:

Design, conduct, and analyze in vitro transfection and transduction experiments using clonal cell lines and primary cells/tissues, and perform readout experiments including cell-based assays, luminescence readouts, immunostaining, epifluorescence and confocal microscopy, flow cytometry, qPCR, and western blot.

Design and conduct single-cell RNA-seq experiments from in vitro and in vivo samples including sample processing, library construction, and data analysis.

Microdissection and sterile culture of mouse tissues

Maintain accurate and timely documentation of activities through meticulous electronic lab notebook practices and contributions to reports.

Maintain an up-to-date understanding of related scientific literature.

Analyze, interpret, present, and discuss experimental data, with the ability to clearly communicate results in written and oral formats for team feedback.

Work collaboratively with team members to find solutions and overcome challenges, including assay development and optimization.

Organize key lab operations including leading and executing coordinated orders of specialized materials and instruments, and generation and maintenance of databases for samples and reagents.

Basic Qualifications:

Bachelors Degree in cellular/molecular biology, neuroscience, medicine or related scientific field with 2+ years of relevant laboratory work experience; biotech or pharmaceutical industry experience preferred.

Additional Skills/Preferences:

Experience with RNA analyses and protein analysis techniques (qPCR, western blot, etc.).

Experience with mouse handling, tissue harvest, and microdissection preferred.

Demonstrated ability to function as a member of an interdisciplinary team and contribute within a highly collaborative and fast-paced environment.

Exceptionally organized and detail oriented.

Excellent computer skills and proficiency in Microsoft Products (Outlook, Excel, Word, PowerPoint, etc.) and electronic notebooks (e.g. Benchling) to support documentation, database tracking of lab operations, samples, and protocols.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is

$71,250 - $187,000

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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