Senior Principal Scientist, AI/ML Antibody Design & Engineering

Regeneron Pharmaceuticals • Tarrytown, NY • 8h ago

We are seeking a highly talented and motivated Senior Principal Scientist specializing in AI Machine Learning to lead the design and engineering of our next-generation antibody-based protein therapies. The ideal candidate shall have a strong background and passion in both computational biology, with expertise in programming, large language models, in silico protein design tools, and knowledge in structural biology and antibody engineering. You will help drive both internal development and external partnership to create/validate AI/ML tools to enable our quest for next-gen antibody therapies. By closely working with antibody engineers, structural biologists and AI/ML scientists from a cross functional team, you have a unique opportunity to shape the future of our AI/ML strategy and deliver on future biotherapies from our state-of-art research facilities.

A typical day in the life of a Senior Principal Scientist AI/ML Antibody Design and Engineering may include the following responsibilties:

Utilize AI and machine learning techniques to design novel antibodies and bi/multi-specific antibodies that would be challenging to achieve from screening

Develop novel AI and machine learning tools to enable de novo antibody discovery with unique properties and in silico co-optimization of affinity, expression, stability and PK/half-life.

Apply deep learning and generative AI techniques to train/enhance LLM or other relevant language models using internal datasets

Use in silico protein/antibody engineering design tools such as Rosetta to drive for structure-based design and engineering

Leverage deep target biology from broad therapeutic areas to enable desired novel MoAs through molecular design

Collaborate and support scientists from antibody engineering, therapeutic areas and other tech centers with biotherapeutic design

Guide and lead AI/ML scientists across multiple functions to have a synergized AI/ML strategy and drive sustained delivery of novel molecular entities to pipeline

Serve as an expert in computational biologic design to keep up with the latest advancements in AI, machine learning, and protein engineering fields

Maintain data analysis and records in well-organized fashion

Present data clearly to teams and managements

This role may be for you if:

You are a result-driven innovator and a problem solver

You have a strong background in computational biology, programming, deep learning algorithms, structural biology and protein engineering

You have expertise with advanced machine learning models related to antibody engineering, such as language model, geometric deep learning, generative model and multi-modal model

You have proficiency in programming languages such as Python, R and C++ You have competence to work with large dataset and cloud computing infrastructure

You can efficiently coordinate multiple projects in a collaborative environment

You have strong organizational, time-management, and presentation skills

You enjoy working in a fast-paced, innovative and cross-functional team

To be considered for this opportunity, you must have a PhD in Computational Biology, Bioinformatics, Computer Science, Structural Biology or a related field, with 7-10 years of relevant experience. You must have a strong track record of innovation and research accomplishments in developing AI/ML methods and using deep learning tools to successfully solve antibody/protein engineering challenges. Experience in using structural modeling and design tools (e.g. Rosetta) is strongly preferred. Experience in constructing DNA and protein production for screening in silico design is preferred.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the @type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)

$148,300.00 - $241,900.00

Similar Jobs

Staff Data Engineer

NBC Universal • Englewood Cliffs, NJ • 8h ago

IT & Engineering

NBCUniversal is one of the world's leading media and entertainment companies. We create world-class content, which we distribute across our portfolio of film, television, and streaming, and bring to life through our them...

8h ago

Go to Apply

Senior Associate Scientist, Therapeutic Antibody (Early Discovery)

Regeneron Pharmaceuticals • Tarrytown, NY • 8h ago

IT & Engineering

We are seeking a highly motivated Senior Associate Scientist to join our Immunoscreening group in the Therapeutic Antibody team. You will contribute to the identification of potential therapeutic antibodies, in-vitro cha...

8h ago

Go to Apply

Data Analyst

WMCHealth • Valhalla, NY • 13h ago

IT & Engineering

Data Analyst Company: NorthEast Provider Solutions Inc. City/State: Valhalla, NY Category: Clerical/Administrative Support Department: Clinical Care Mgmt-WMC Health Union: No Position: Full Time Hours: M-F, 8-4 Shift: Da...

13h ago

Go to Apply

Senior Engineer, Manufacturing Engineering

Stryker • Mahwah, NJ • 1w ago

IT & Engineering

What you will do: You will provide manufacturing engineering leadership and lead multiple complex projects for assigned cells within our Mahwah, NJ site. You will work closely with quality assurance, suppliers, advanced...

1w ago

Go to Apply

Electrical and Instrumentation Technician (24-1228)

Wheelabrator Gloucester Company, L.P. • Peekskill, NY • 1w ago

IT & Engineering

Full Job DescriptionWIN Waste Innovations is looking for an Electrical and Instrumentation Technician who is skilled, detail oriented, and self-motivated individual. The basic function of the E&I Technician is to ins...

1w ago

Go to Apply

3rd Class Electrical and Instrumentation Technician - 25-523

Wheelabrator Gloucester Company, L.P. • Peekskill, NY • 1w ago

IT & Engineering

1w ago

Go to Apply

Senior Software Engineer - TIBCO Engineer

Capgemini • Englewood Cliffs, NJ • 1w ago

IT & Engineering

We are seeking an experienced TIBCO Engineer to join us for a fulltime, hybrid role. KEY RESPONSIBILITIES: · Provide proactive support for TIBCO BW applications, ensuring optimal system performance and minimal downtime....

1w ago

Go to Apply

Big Data Engineer - Medicare/Medicaid

Molina Healthcare • Yonkers, NY • 1w ago

IT & Engineering

Job Summary We are seeking a highly skilled and forward-thinking Big Data Engineer to join our healthcare data team. This role encompasses the end-to-end design, development, and management of large-scale data systems ta...

1w ago

Go to Apply

Manufacturing Technician

Adecco US, Inc. • Pearl River, NY • 1w ago

IT & Engineering

Adecco Healthcare & Life Sciences is hiring a remote contract Manufacturing Technician I for our Pharmaceutical partner based in Pearl River, NY. The anticipated hourly wage for this position is between $26 and $27.5...

1w ago

Go to Apply

Software Engineer

Photo Studio Universe Picsello • Larchmont, NY • 1w ago

IT & Engineering

Photo Studio Universe Picsello needs 1 Software Engineer. Duties include managing CRM development team, performing requirement analyses, design, development and test manage. Estimate feasibility analyses, forecast risk....

1w ago

Go to Apply

Subscribe to get new jobs sent directly to you
(no charge, cancel anytime)

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.