Principal Program Manager Engineering Projects

ImmunityBio, Inc. (NANTKWEST, Inc.) • Dunkirk, NY • 10h ago

Company Overview ImmunityBio is a vertically integrated commercial stage biotechnology company developing next-generation therapies that bolster the natural immune system to defeat cancers and infectious diseases. The Company's range of immunotherapy and cell therapy platforms, alone and together, act to drive and sustain an immune response with the goal of creating durable and safe protection against disease. Designated an FDA Breakthrough Therapy, ANKTIVA is the first FDA-approved immunotherapy for non-muscle invasive bladder cancer CIS that activates NK cells, T cells, and memory T cells for a long-duration response. The Company is applying its science and platforms to treating cancers, including the development of potential cancer vaccines, as well as developing immunotherapies and cell therapies that we believe sharply reduce or eliminate the need for standard high-dose chemotherapy. These platforms and their associated product candidates are designed to be more effective, accessible, and easily administered than current standards of care in oncology and infectious diseases. Why ImmunityBio? ImmunityBio is developing cutting-edge technology with the goal to transform the lives of patients with cancer and develop next-generation therapies and vaccines that complement, harness and amplify the immune system to defeat cancers and infectious diseases. Opportunity to join a publicly traded biopharmaceutical company with headquarters in Southern California. Work with a collaborative team with the ability to work across different areas of the company. Ability to join a growing company with professional development opportunities. Position SummaryThe Principal Program Manager, Engineering Projects leads a portfolio of complex capital, facility, utility, equipment, and technical-infrastructure programs that enable ImmunityBio's clinical and commercial GMP manufacturing operations. This role provides strategic program leadership from concept development and capital approval through design, construction, commissioning, qualification, operational handover, and closeout. The Principal Program Manager establishes integrated governance, portfolio priorities, execution strategy, project controls, and executive decision support; leads cross-functional internal teams and external engineering, construction, CQV, and vendor partners; and ensures programs are delivered safely, compliantly, on schedule, within approved capital budgets, and in alignment with business, quality, and regulatory requirements.Essential Functions Lead a portfolio of capital, facility, utility, equipment, and technical-infrastructure programs that enable clinical and commercial GMP manufacturing, from concept and business case through construction, CQV, operational turnover, and closeout Establish the program strategy, integrated roadmap, governance model, decision cadence, portfolio priorities, resource plan, and performance measures in alignment with business objectives. Develop and maintain integrated project controls, including scope, WBS, schedule, critical path, cost forecast, cash flow, resource requirements, risks, assumptions, dependencies, changes, and mitigation plans. Lead cross-functional delivery across Engineering, Facilities, Manufacturing, Quality, Validation, EHS, Supply Chain, Finance, Procurement, and external architecture, engineering, construction, and equipment-vendor partners. Integrate GMP, Quality, and CQV requirements into project plans, including design qualification where applicable, commissioning, IQ/OQ/PQ, documentation review, deviation/change-control dependencies, and readiness for release to operations. Provide executive-ready portfolio reporting, decision briefs, scenario analyses, risk escalations, and recommendations on scope, schedule, cost, capacity, and compliance tradeoffs. * Direct capital planning and financial controls, including business cases, appropriation requests, budget

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