Postdoctoral Fellow - Leukemia - Research

MD Anderson Cancer Center • Houston, TX • 5h ago

A postdoctoral fellow position is available in the Section of Molecular Hematology & Therapy, Department of Leukemia at the University of Texas MD Anderson Cancer Center under the mentorship of Michael Andreeff, MD, Ph.D.

We are seeking a highly motivated and innovative individual with advanced clinical experience in hematologic malignancies and technical expertise in cell, molecular, or cancer biology to lead a project focused on developing new analytical modalities for identifying novel vulnerabilities and creating hypothesis-driven, mechanism-based molecular targeting strategies for drug-resistant leukemias.

The postdoctoral fellow will conduct research on cell death and cell survival pathways, as well as mechanisms of drug resistance in myeloid leukemia stem cells, through a combinatorial study using molecular biology methodologies. These include gene editing, mutation detection, gene and protein expression analysis, chromatin accessibility profiling, and evaluation of responses to drug treatments in both in vitro and in vivo leukemia cell systems. The goal is to broaden understanding of cell death regulators, signaling pathways, and leukemia microenvironmental factors, clarify their roles in drug resistance, and develop a mechanism-based approach to overcome therapeutic resistance.

All duties and responsibilities are carried out in compliance with institutional policies, ethical research standards, and applicable federal and state regulations.

LEARNING OBJECTIVES

Learn how to collaborate with established and committed investigators in an interdisciplinary project involving cell culture, flow cytometry, mass cytometry, western blot analysis, immunohistochemistry, RT-PCR, DNA/RNA sequencing, and patient-derived xenograft leukemia and murine leukemia models using animals.

Learn how to write report scientific results and will present findings in project meetings, national and international conferences, and high-impact scientific publications.

ELIGIBILITY REQUIREMENTS

The ideal candidate is a recently graduated physician-scientist with an M.D. and/or Ph.D. degree, possessing expertise in cell, molecular, and cancer biology, along with a strong practical background and comprehensive knowledge of cell death pathways and cell signaling.

The candidate should also demonstrate proficiency in a series of laboratory techniques, including cell culture, drug treatment, and cell death assays, molecular cloning, flow cytometry, and/or experience with murine models of leukemia. Data analytic skills using innovative analytical approaches are highly desirable. The applicant enjoys providing both practical and theoretical training to students, fosters scientific collaboration within the research group, and exhibits excellent written and spoken English communication skills. Additionally, the candidate should have one or more first-author publications in high-impact, peer-reviewed journals in the field of hematology.

POSITION INFORMATION

MD Anderson offers full-time postdoc positions with a https://www.utsystem.edu/offices/employee-benefits/ut-retirement-program/voluntary-retirement-programs, tuition benefits, educational opportunities, and individual and team recognition

Offsite work arrangements are subject to approval and may be modified or revoked at any time based on business needs, performance considerations, or regulatory requirements.

This position may be responsible for maintaining the security and integrity of critical infrastructure, as defined in Section 113.001(2) of the Texas Business and Commerce Code and therefore may require routine reviews and screening. The ability to satisfy and maintain all requirements necessary to ensure the continued security and integrity of such infrastructure is a condition of hire and continued employment.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html

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