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Job Description
The ODPD group is responsible for design & development formulation and manufacturing processes of oral solid dosage forms (OSDs) support early and late phase clinical studies using various synthetic molecule pipeline assets.
The intern will have the opportunity to work on development of material sparing tableting process development.
Compaction simulators are widely used in tablet development due to their low material use and flexibility. Yet, they often fail to replicate the flow and shear forces present in production presses, resulting in tablets whose quality diverges from those made on production equipment.
This project aims to develop a method to properly condition powder blends before compression in a compaction simulator. We will conduct experiments involving extended shearing and develop stress-scaling relations. The method will be validated using a pilot- or production-scale press.
The data sets generated during this project will be collated in a database, along with prior internal results to support machine learning based predictions for selection of initial process parameters for unknown blends.
How You Will Contribute:
Duties may include the following, under the manager's supervision
Run various experiments on the compaction simulator to manufacture tablets and characterize material properties like yield pressure, strain rate sensitivity etc.
Manufacture tableting mixtures using various mixing and granulation techniques.
Run characterization experiments including bulk and true density, shear cell, hardness, disintegration, dissolution, particle size distribution etc.
Use process modeling techniques like discrete element method (DEM) to understand the die filling process and Finite Element Analysis (FEA) and compression cycle.
Internship Development Opportunities:
The intern will collaborate closely with multiple experts within the ODPD group and other cross functional team members within R&D to and understand how the groups collaborate to enable support of pipeline programs
Gain laboratory experience across various unit operations involved in OSD manufacturing like mixing, granulation, tableting etc.
The intern will get exposed to material sparing characterization and development approaches, which include use of compaction simulator and process modeling like DEM, FEA
Job Requirements:
?This position will be Fully Onsite and require 4+ days in the Cambridge office per week.?
Must be pursuing a Master's or Doctoral Degree in a relevant Field of Study
A foundational knowledge of pharmaceutical product development. Knowledge of pharmaceutics/ chemical or mechanical engineering/ bulk solids/ materials characterization and modeling is preferred.
Demonstrated ability to work effectively as a collaborative team member.
Comfortable working in a laboratory environment
Willingness to wear personal protective equipment (PPE) appropriate for powder laden environments, such as safety glasses, gloves, masks closed toe shoes, etc.
Internship Eligibility ?
Must be authorized to work in the U.S. on a permanent basis without requiring sponsorship?
Must be currently enrolled in a degree program graduating December 2026 or later?
The internship program is 10-12 weeks depending on the two start dates (May 26th-August 14th or June 15th- August 21st) ?
The intern must be able to commit to one of these time frames??
Able to work full time 40 hours a week during internship dates??
Takeda does not provide a housing stipend or relocation support for the U.S Summer Internship Program?
?Program Highlights: ?
Hands-on experience with real projects and responsibilities?
Dedicated mentorship program pairing interns with experienced professionals?
Networking opportunities with industry professionals and fellow interns?
Internship events focused on professional and skills development??
Exposure to multiple business areas or departments within a Pharmaceutical Organization?
Applications will be accepted between October 31st- November 16th
Takeda Compensation and Benefits Summary
We understand compensation may be?an important factor?as you consider an internship opportunity. We are committed to?equitable?pay for all employees, and we strive to be more transparent with our pay practices.
For Location:
Boston, MA
U.S. Hourly Wage Range:
$21.00 - $46.00
The estimated hourly range reflects?an anticipated?range for this position. The actual hourly wage offered will depend on the candidate's school year/level to be entered following completion of internship. The actual hourly wage offered will be?in accordance with?state or local minimum wage requirements for the job location.
U.S. internship benefits vary by location and may include:
Paid sick time
Civic Duty paid time off
Participation at company volunteer events
Participation at company sponsored special events
Access to on-site fitness center (where available)
Commuter Benefit: To offset your work-commute expenses, Takeda provides U.S. employees with a fixed monthly subsidy to be used for either public transportation (transit) or parking.
EEO Statement
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Locations
Boston, MA
Worker Type
Employee
Worker Sub-Type
Paid Intern (Fixed Term) (Trainee)
Time Type
Full time
Job Exempt
No
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
