Postdoctoral Researcher

MCW: SARGEANT HEALTH CENTER • Milwaukee, WI • 4h ago

JOB REQUIREMENTS: Position Description: Every great life-changing
discovery begins the same way-with new knowledge. It can change
everything, from a single life to the future of entire communities.
That\'s why academic medicine, and the continuous pursuit of knowledge,
is at the center of everything we do at the Medical College of Wisconsin
(MCW). In the role ofa Postdoctoral Researcheryou will beworking in Cell
Biology, Neurobiology and Anatomy. Purpose Post-doctoral position is
available in the Department of Cell Biology focused on chemical
synthesis of probe compounds targeting G protein-coupled receptors
(GPCRs). Our lab is a highly-creative and and dynamic Drug Discovery lab
involved in cutting-edge technologies collaborating internationally on
projects with other labs. We specialize in GPCR signaling and structural
determinants of biased agonism to design and screen compounds as
potential drugs at various GPCR signaling pathways aimed at treating
depression, pain, cancer, and various other diseases. This post-doctoral
position will synthesize various chemical probes that are designed to
have selectivity or unique signaling properties at various GPCR targets.
Projects will involve chemical synthesis of analog libraries of various
chemo@types, scale-up for in vivo studies, and using structure-based and
virtual screening to identify new chemo@types. Post-docs will be expected
to synthesize compounds for several projects, publish and collaborate on
high-impact discoveries from the lab and have the opportunity to develop
their own project goals. We welcome highly-motivated and well-organzied
candidates capable of independent work in a laboratory setting.
Candidates should have strong interests in medicinal chemistry and/or
pharmacology, demonstrate strong track records in chemical and organic
synthesis, with expertise in small molecule synthetic routes and
analytical purification and separation techniques. Primary Functions
Synthesize small molecular chemical probes and analogs Perform advanced
small molecule purification and analytical techniques using NMR and Mass
Spectrometry, and HPLC chiral separation. Analyze structure-activity
relationships (SARs) and propose novel compounds and synthetic routes.
Perform data analysis, and data archiving according to supervisors\'
specifications Participate in international collaborations and
communication with the principal investigators and fellow scientists
when needed for projects. Participate in regular one-on-one and lab
meetings with principal investigator and research staff and
evaluate/interpret the validity of data, develop methodologies, and
evaluate lab... For full info follow application link. EEO/AA
Minorities/Females/Vets/Disability The Medical College of Wisconsin is
an affirmative action/equal opportunity employer and does not
discriminate in hiring or employment on the basis of age, sex, race,
color, religion, national origin, veteran status, disability or sexual
orientation. *** APPLICATION INSTRUCTIONS: Apply Online:
ipc.us/t/AEA3EF95DA284B96 Qualified females, minorities, and special
disabled veterans and other veterans are encouraged to apply.

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