Research Assistant III - Immunobiology - Grimes Lab

Cincinnati Children's Hospital Medical Center • Cincinnati, OH • 9h ago

Job Description At Cincinnati Children's, we come to work with one goal: to make children's health better. We believe in a holistic team approach, both in caring for patients and their families, and in advancing science and discovery. We strive to do better and find energy and inspiration in our shared purpose. If you want to be the best you can be, you can do it at Cincinnati Children's. Cincinnati Children's is:

Recognized by U.S. News & World Report as a top 10 best children's hospitals in the nation for more than 15 years

Second Among All Children's Hospitals for National Institutes of Health (NIH) Funding

Recognized as one of America's Best Large Employers (2025) , America's Best Employers for New Grads (2024)

One of the nation's America's Most Innovative Companies as noted by Fortune

Consistently certified as great place to work

A Leading Disability Employer as noted by the National Organization on Disability

Magnet designated for the fourth consecutive time by the American Nurses Credentialing Center (ANCC)

JOB RESPONSIBILITIES The Grimes lab is seeking a research assistant to oversee and manage the animal colony supplying experimental mice for scientific studies focused on understanding the biological mechanisms responsible for normal and malignant hematopoiesis. We utilize transgenic mouse models, patient samples, multi-omics approaches, and iPSC/organoid technologies to determine the effect of infection and molecular oncology on hematopoiesis. Our research team's goal is to provide relevant functional insight into hematological diseases like myelodysplastic syndromes (MDS), severe congenital neutropenias (SCN), and acute myeloid leukemia (AML) that may inform new avenues for therapeutic intervention. The RA will assist with animal work such as weaning, mating, and monitoring mice, as well as identifying, genotyping, and validating novel genetic mouse models through molecular biology assays including PCR, Gel Electrophoresis, rt-PCR, Sanger Sequencing, and Flow Cytometry. A strong understanding of genetics and basic molecular biology is essential, and mouse handling experience and flow cytometry experience is preferred. Perform experiments and record data Follow established research protocols. Understand the scientific principles involved in the research. Apply those principles to troubleshoot and modify procedures and techniques when appropriate. Maintain accurate and detailed records of all laboratory work and experiments in both physical lab notebook and location of data on the laboratory's shared drive. Analyze data and perform statistical and graphical analysis of data. Design and execute daily laboratory experiments in coordination with senior laboratory personnel. Apply standard protocols to specific experiments with the capability of reproducing experimental results. Maintains an active role in the laboratory's meetings, presentations, and publications. Contributes material for reports, publications, journal articles, and abstracts. Able to orally present data in group presentations. Assists in training new laboratory personnel in laboratory techniques and equipment. Prior experience with PCR, Gel Electrophoresis, and Flow Cytometry is preferred. *Lab Administration Troubleshoot and/or make modifications as necessary to established procedures. Maintain inventory of laboratory supplies and equipment. Operate, maintain, and troubleshoot standard laboratory equipment. Be willing and able to assist in daily operations of the laboratory including answering the phone, maintaining lab supplies, lab stocks, organization, and cleanliness. Maintains optimal protocol and assay accuracy by conducting regular quality checks. Provides appropriate safety monitoring Apply here: https://www.aplitrak.com/?adid=YmJnZW5lcmljLjU0NDM3LjEwNTA4QGNpbmNpbm5hdGljaGlsZHJlbnNjb21wLmFwbGl0cmFrLmNvbQ

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